Pathophysiology

Pathophysiology/emergence of an allergic reaction

The asthma has an inflammation reaction of the bronchial mucosa in which mast cells, T lymphocytes, granulocytes and inflammation mediators like histamine play a role central importance at the emergence (see chapter "immune system"). A bronchial hyperreactivity is found at all asthmatics at the beginning and in the further course of the illness, i.e. the bronchial system already reacts at lowest and real not harmful, neutral stimuli with a narrow position and mucus overproduction.

One is the allergic IgE asthma the decisive role in the pathogenesis immediately type reaction arranged type I. IgE which its messenger substances, e.g. histamine, tip out after that recognizes specific allergens as body foreign, ties them to itself and presents them to the mast cells so. These so-called mediators trigger a reaction chain and cause an endobronchial obstruction through
  • Bronchospasm (convulsive narrow places of the middle and small air routes)
  • Mucosa tumescence and inflammatory infiltrate of the mucosa
  • Overshooting formation of a tough mucus
The respiratory systems are transferred through this and it comes to the acute air need. It still can switched asthmatic immediate reaction of the type I after few minutes come to IgG switched delayed reactions besides the IgE, hours after allergen exposure, too. Some patients show both reaction shapes.

A single triggering allergen usually is in the beginning of a purely allergic asthma, in the course of the years, it often comes, however, to an expansion of the spectrum of triggering allergens through which a prophylaxis gets more and more difficult by allergen elimination.


These informations may be considered a substitute for a piece of medical advice in no case. The content of health-illness.com doesn't can and may be put into any case to make diagnoses or carry out self medical treatment independently.


Diese Informationen dürfen auf keinen Fall als Ersatz für ärztliche Beratung angesehen werden. Der Inhalt von medhost.de kann und darf auf keinen Fall verwendet werden, um eigenständig Diagnosen zu stellen oder Selbstbehandlung durchzuführen.

Medhost ¦ Startseite - Newsletter - Impressum - Disclaimer - Kontakt - Sprache ¦ Deutsch - English
1999 - 2007 Copyright Promeus AG, Alle Rechte vorbehalten